Wissenschaft und Forschung

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines.
Aksglaede L, Kanakis G, Rajpert-De Meyts E, Jezek D, Algaba F, Dohle G, Slowikowska-Hilczer J, Kliesch S, Behre HM, Krausz C, Goulis DG, Jørgensen N.Andrology. 2026 Oct;14(7):1906-1928. doi: 10.1111/andr.70300. Epub 2026 Jul 20. PMID: 42473722 Free PMC article.

Extracellular cues and cellular conversations: the molecular choreography of embryo implantation.
Jeschke JK, Nordhoff V, Götte M, Kyriakopoulou K.Am J Physiol Cell Physiol. 2026 Oct 1;331(4):C1047-C1060. doi: 10.1152/ajpcell.00048.2026. Epub 2026 Sep 2.PMID: 42684058 Free article. Review.

Therapeutic options for CatSper-related male infertility – only ICSI leads to successful outcomes
V Nordhoff , T Pock , K Fechtmann , C Krallmann , T Sperlbaum , H M Behre , S Kliesch 
Reproductive BioMedicine Online, April 2026

Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/082, May 2025).
Lotz L, Kliesch S, Baston-Buest D, Schüring A, Balcerek M, Bartsch B, Baumann R, Beckmann M, Behringer K, Borgmann-Staudt A, Böttcher B, Corradini S, Cremer W, Dinkel A, Diesch-Furlanetto T, Frenz S, Germeyer A, Goeckenjan M, Hepp V, Hetzer F, Jarisch A, Kentenich H, Knuth UA, Korell M, Köhn FM, Bender-Liebenthron J, Lindel K, Leszinski GS, Lux M, Meißner J, Micke O, Müller A, Nawroth F, Nordhoff V, Oppelt P, Reisch N, Reiser E, Reschke F, Rink A, Sahi A, Sänger N, Soave A, Roxana S, Sigg C, Sikora M, Tauchert S, Thorn P, Weberschock T, Wimberger P, Wischmann T, Würstlein R, von Wolff M, Dittrich R.Geburtshilfe Frauenheilkd. 2026 Apr 15;86(4):333-375. doi: 10.1055/a-2811-6101. eCollection 2026 Apr.PMID: 42024029 Free PMC article.

From Preservation to Creation: The Expanding Frontier of Fertility Preservation - Proceedings of the 2nd Montreux Reproductive Summit, 29-30 August 2025.
Vallée A, Saridogan E, Mueller MD, Calhaz-Gorges C, Wyns C, Dolmans MM, Grimbizis G, Spits C, Amorim CA, Nordhoff V, Andersen CY, Brännström M, Moawad G, Ayoubi JM, Feki A; Montreux Summit Working Group.Facts Views Vis Obgyn. 2026 Mar 2;18(Suppl 1):1-14. doi: 10.52054/FVVO.2026.260126.PMID: 41766597 Free PMC article.

Development of medical freezing measures in women during the last decade from 2014 to 2023: registry data of the tri-national network FertiPROTEKT.
Vidal A, Nordhoff V, Suerdieck M, Pape J, von Wolff M.Arch Gynecol Obstet. 2026 Jan 13;313(1):36. doi: 10.1007/s00404-025-08253-7.PMID: 41528507 Free PMC article.

Genotype-specific differences in infertile men due to loss-of-function variants in M1AP or ZZS genes.
Rotte N, Dunleavy JEM, Runkel MD, Bosse L, Fietz D, Pilatz A, Kuss J, Dicke AK, Winge SB, Di Persio S, Ruckert C, Nordhoff V, Schuppe HC, Almstrup K, Kliesch S, Neuhaus N, Stallmeyer B, O'Bryan MK, Tüttelmann F, Friedrich C.EMBO Mol Med. 2025 Jun;17(6):1417-1451. doi: 10.1038/s44321-025-00244-0. Epub 2025 May 15.PMID: 40374915 Free PMC article.

Initial motility and vitality predict the semen quality after long-term cryostorage, even in patients with restricted ejaculate parameters.
Bier S, Hanke D, Zitzmann M, Kliesch S, Nordhoff V.Andrology. 2025 Nov;13(8):2131-2141. doi: 10.1111/andr.70019. Epub 2025 Mar 6.PMID: 40047341 Free PMC article.

EndoCompass project: research roadmap for reproductive and developmental endocrinology.
Cools M, Krausz C, Juul A, Macut D, Andersen MS, Andersson AM, Andoniadou CL, Ahmed SF, Bakker J, Bashamboo A, Behre HM, Bonomi M, Busch AS, De Roo C, Dessens A, Fakhar-I-Adil M, Fanelli F, Fisher AD, Flück C, Gambineri A, Giwercman A, Gravholt CH, Hannema S, Heindryckx B, Hiort O, Hornig NC, Howard S, Ibáñez L, Blomberg Jensen M, Jørgensen N, Livadas S, Lucas-Herald A, Mastorakos G, Meriggiola MC, Ong K, Opalic Palibrk M, Pignatelli D, Pitteloud N, Rajpert-De Meyts E, Rey R, Robeva R, Pozza C, Schlatt S, Spaggiari G, Tack L, Tena-Sempere M, Tournaye H, T'Sjoen G, Van Mello N, Vena W, Yildiz BO, de Zegher F.
Eur J Endocrinol. 2025 Oct 17;193(Supplement_2):ii97-ii116. doi: 10.1093/ejendo/lvaf069. 
PMID: 41104478 Free article.

The sperm-specific K+ channel Slo3 is inhibited by albumin and steroids contained in reproductive fluids.
Lorenz J, Eisenhardt C, Mittermair T, Kulle AE, Holterhus PM, Fobker M, Boenigk W, Nordhoff V, Behre HM, Strünker T, Brenker C.Front Cell Dev Biol. 2024 Aug 29;12:1275116. doi: 10.3389/fcell.2024.1275116. eCollection 2024.PMID: 39310227 Free PMC article.

P-027 Sperm motility and calcium ionophore treatment influence fertilization and pregnancy outcomes in TESE-ICSI 
T Pock , K Fechtmann , E Plester , T Sperlbaum , H  M Behre , S Kliesch , V Nordhoff
Human Reproduction, Volume 39, Issue Supplement_1, July 2024, deae108.406, doi.org/10.1093/humrep/deae108.406

Evaluation of the Gonadotoxicity of Cancer Therapies to Improve Counseling of Patients About Fertility and Fertility Preservation Measures: Protocol for a Retrospective Systematic Data Analysis and a Prospective Cohort Study.
von Wolff M, Germeyer A, Böttcher B, Magaton IM, Marcu I, Pape J, Sänger N, Nordhoff V, Roumet M, Weidlinger S.JMIR Res Protoc. 2024 Mar 20;13:e51145. doi: 10.2196/51145.PMID: 38506900 Free PMC article.

Identification of two hidden clinical subgroups among men with idiopathic cryptozoospermia.
Schülke LC, Wistuba J, Nordhoff V, Behre HM, Cremers JF, Kliesch S, Di Persio S, Neuhaus N.Hum Reprod. 2024 May 2;39(5):892-901. doi: 10.1093/humrep/deae013.PMID: 38365879 Free PMC article.

Frequency, morbidity and equity - the case for increased research on male fertility.
Kimmins S, Anderson RA, Barratt CLR, Behre HM, Catford SR, De Jonge CJ, Delbes G, Eisenberg ML, Garrido N, Houston BJ, Jørgensen N, Krausz C, Lismer A, McLachlan RI, Minhas S, Moss T, Pacey A, Priskorn L, Schlatt S, Trasler J, Trasande L, Tüttelmann F, Vazquez-Levin MH, Veltman JA, Zhang F, O'Bryan MK.
Nat Rev Urol. 2024 Feb;21(2):102-124. doi: 10.1038/s41585-023-00820-4. Epub 2023 Oct 12.
PMID: 37828407 Review.

Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation.
Young S, Schiffer C, Wagner A, Patz J, Potapenko A, Herrmann L, Nordhoff V, Pock T, Krallmann C, Stallmeyer B, Röpke A, Kierzek M, Biagioni C, Wang T, Haalck L, Deuster D, Hansen JN, Wachten D, Risse B, Behre HM, Schlatt S, Kliesch S, Tüttelmann F, Brenker C, Strünker T.J Clin Invest. 2024 Jan 2;134(1):e173564. doi: 10.1172/JCI173564.PMID: 38165034 Free PMC article.

GM-CSF perturbs cell identity in mouse pre-implantation embryos.
Pock T, Schulte K, Schlatt S, Boiani M, Nordhoff V.PLoS One. 2022 Feb 10;17(2):e0263793. doi: 10.1371/journal.pone.0263793. eCollection 2022.PMID: 35143564 Free PMC article.

Fertility preservation and management of pregnancy in melanoma patients requiring systemic therapy.Hassel JC, Livingstone E, Allam JP, Behre HM, Bojunga J, Klein HH, Landsberg J, Nawroth F, Schüring A, Susok L, Thoms KM, Kiesel L, Berking C.
ESMO Open. 2021 Oct;6(5):100248. doi: 10.1016/j.esmoop.2021.100248. Epub 2021 Aug 23.
PMID: 34438241 Free PMC article. Review.

Early testicular maturation is sensitive to depletion of spermatogonial pool in sickle cell disease.
Benninghoven-Frey KM, Neuhaus N, Lahtinen AK, Krallmann C, Portela JMD, Jarisch A, Nordhoff V, Soave A, Ba Omar HAM, Sundin M, Langenskiöld C, Kliesch S, Stukenborg JB, Jahnukainen K.Haematologica. 2022 Apr 1;107(4):975-979. doi: 10.3324/haematol.2021.279253.PMID: 34879646 Free PMC article. No abstract available.

The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm.
Jeschke JK, Biagioni C, Schierling T, Wagner IV, Börgel F, Schepmann D, Schüring A, Kulle AE, Holterhus PM, von Wolff M, Wünsch B, Nordhoff V, Strünker T, Brenker C.Front Cell Dev Biol. 2021 Jul 26;9:699554. doi: 10.3389/fcell.2021.699554. eCollection 2021.PMID: 34381781 Free PMC article.

Effect of Genetic Variants of Gonadotropins and Their Receptors on Ovarian Stimulation Outcomes: A Delphi Consensus. Conforti A, Tüttelmann F, Alviggi C, Behre HM, Fischer R, Hu L, Polyzos NP, Chuderland D, Rama Raju GA, D'Hooghe T, Simoni M, Sunkara SK, Longobardi S.
Front Endocrinol (Lausanne). 2022 Feb 1;12:797365. doi: 10.3389/fendo.2021.797365. eCollection 2021.
PMID: 35178027 Free PMC article.

Cyproteronacetat und Meningeomrisiko
Sperlbaum T, Kiesel L
Gynäkologische Endokrinologie,  Januar 2021